Christian McCaffrey DVOA, Advanced Stats, & Fantasy Rankings

San Francisco 49ers running back Christian McCaffrey had his biggest game of the season in Week 6 against the Commanders. McCaffrey gained 118 scrimmage yards, extended his scoring streak to a fifth game with two touchdown runs, and logged 25 touches - his most in a game all year. McCaffrey led the team with nine catches and 10 targets with Deebo Samuel Sr. (hamstring) out of the lineup and Mike Evans (ribs, Achilles) forced out early due to injury. Both wide receivers will be out for Week 7, which puts McCaffrey in position to act as Brock Purdy's primary target. The Atlanta Falcons are tied for the fourth most receptions allowed to opposing running backs through Week 6. McCaffrey has four top-10 finishes under his belt already in 2026, and is projected for another one in Week 7. He should be locked into starting lineups.

San Francisco 49ers running back Christian McCaffrey had 68 rushing yards and a touchdown on 11 carries and three catches for 15 receiving yards on five targets last week. In Week 6, the 49ers face the Commanders, who have been surprisingly effective against the run. Washington has allowed just two rushing touchdowns, the sixth-fewest rushing yards, and the fourth-fewest fantasy points to opposing running backs in 2026. McCaffrey's utility as a receiver will keep him in play as a top option at his position. The Commanders are in the middle of the pack defending against passes to running backs, and Deebo Samuel Sr. (hamstring) has been ruled out, and Mike Evans (ribs, Achilles) is questionable, which means more targets could come CMC's way. McCaffrey projects as an RB1 and should be started in fantasy football in Week 6.

San Francisco 49ers running back Christian McCaffrey was held out of the end zone in Week 1 but has scored at least one touchdown in each of his last three games. Going back to 2025, McCaffrey has scored in 15 of the 49ers' last 21 games. Extending his current touchdown streak against the Seahawks in Week 5 will be difficult, but not impossible. McCaffrey's 15 touches inside the 20 rank 15th among all NFL players and represent a 35% team share in red zone opportunities. He should see another handful of chances to punch one in on Sunday. McCaffrey's talents as a receiver will be in play on Sunday, as the Seahawks have allowed the fourth-most receptions to running backs in 2026, whereas they have given up the lowest success rate on rushing attempts. CMC has his work cut out for him in Week 5, but he is an integral part of the 49ers' offense and can still be counted on for RB1 production.